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. 2020 Nov 25;40(48):9306–9316. doi: 10.1523/JNEUROSCI.1046-20.2020

Figure 3.

Figure 3.

T. brucei infection reduces the number of REM episodes and the duration of SWS. In the light phase, there were no effects of infection on the total number (A) or duration (B) of waking episodes. C, Following infection, mice showed a shift toward lower frequency activity during waking (two-way ANOVA; interaction of time and group F(98,882) = 3.188, p < 0.0001). D, There was also no effect of infection on the total number of SWS episodes, (E) but infection reduced the duration of SWS (one-way ANOVA, F(3,34) = 4.119, *p = 0.0088) and (F) shifted activity toward higher frequencies during SWS (two-way ANOVA; interaction of time and group F(98,882) = 3.322, p < 0.0001). G, Infected mice also displayed a reduced number of REM episodes (one-way ANOVA, F(3,34) = 18.43, ***p < 0.0001), but (H) there were no effects of infection on total REM duration, (I) while in infected animals activity was shifted to lower lower frequency during REM (interaction of time and group F(98,882) = 3.912, p < 0.0001). There were no effects of infection on any of these measures in the dark; * denotes group differences after multiple corrections.