Figure 5.

In vivo effects of βOHB on striatal dopaminergic system in aralar-KO mice. A, Striatum DA, DOPAC, and DOPAC/DA in WT and aralar-KO striatum after 290 mg/kg/d βOHB intraperitoneal injections. Data presented as % of WT. Mean ± SEM (n = 5–7 mice per group); ***p ≤ 0.001, *p ≤ 0.05 (one-way ANOVA followed by post hoc Bonferroni-corrected t test). B, Representative Western blotting images of VMAT2 and DARPP-32, with their respective densitometric histograms (C, D), in WT and aralar-KO striatum after βOHB intraperitoneal injections. β-Actin used as charge control. Mean ± SEM (n = 6–9 mice per group); *p ≤ 0.05 (one-way ANOVA followed by post hoc Bonferroni-corrected t test). ns, not significant.