Table 1.

Contrasting features of cardiac amyloidosis and inflammatory‐metabolic heart failure with a preserved ejection fraction

	Wild‐type transthyretin amyloid cardiomyopathy	Inflammatory‐metabolic heart failure with a preserved ejection fraction
Demographic features	Older adults, men > women	Middle‐aged to elderly, women > men
Clinical presentation	Heart failure, typically with increased right‐sided pressures	Heart failure, often with increased right‐sided pressures
Obesity or visceral adiposity	Not characteristic	Characteristically present
Systolic blood pressure	Low to normal (often intolerant of antihypertensive drugs)	Modestly increased (or taking antihypertensive drugs)
Systemic inflammation	Not well characterized	Increased C‐reactive protein and other inflammatory biomarkers
Systemic venous capacitance	Not impaired	Impaired, leading to increased central blood volume
Natriuretic peptides	Often strikingly increased	Disproportionately lower than cardiac filling pressures
Cardiac troponin	Typically increased	Occasionally increased
LV systolic function	Ejection fraction typically >40%	Ejection fraction typically >40%
Left atrial enlargement	Typically present	Typically (but not invariably) present
LV diastolic filling abnormalities	Typically present	Typically present, but often not at rest
LV wall thickness	Markedly increased (especially in men)	Often within the normal range or mildly increased
LV end‐diastolic volumes (indexed for age and gender)	Typically reduced	Normal to mildly increased

LV, left ventricular.