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. 2020 Feb 11;46(6):522–545. doi: 10.1111/nan.12592

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© 2019 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Timeline of landmark discoveries in neurodegenerative diseases. Graphical representation of the history of the discoveries and descriptions of diseases or symptoms, hallmark pathology, proteins, underlying genetic causes and first reported transmissions, as indicated in the left column. The timescale is represented as a Renard series to visualise recent discoveries in higher temporal resolution. Various discoveries related to different misfolded protein pathologies are represented colour‐coded, as indicated at the bottom of the figure. Row 1, first descriptions of the disease or symptom complexes, with separate representation of the time of the initial report and time of the introduction of the eponym, shown below in a corresponding lighter shade. Row 2 shows the timeline of the description of hallmark neuropathology for each disease. Row 3, the first discovery of the protein (for tau, α‐synuclein and TDP43 this precedes association of the misfolded protein with a specific disease). Row 4, the discovery of pathogenic mutations in various genes causing neurodegenerative diseases. The establishment of the journal Neuropathology Applied Neurobiology is displayed here to provide the context to other discoveries. Rows 5 and 6 display experimental transmission (from humans to rodents and primates, respectively) and row 7 indicates the first descriptions of human transmission. References: A 154; B 155, 156; C 156, 157; D 158; E 159, 160; F 161; G 162; H 163; I 164; J 165, 166; K 167; L 168; M 169; N 170; O 171, 172; P 173, 174; Q 175, 176; R 177, 178; S 179; T 170, 180, 181; U 174, 182; V 156, 183; W 184; X 185, 186; Y 185, 186; Z 187; AA 188; AB 189, 190, 191; AC 9, 10; AD 192; AE 193; AF 10; AG 11; AH 11; AI 175, 176; AJ 6; AK 194; AL 7, 195; AM 14; AN 13; AO 12; AP 196; AQ 10; AR 197; AS 11; AT 16; AU 198, 201; AV 202, 203; AW 204, 205; AX 187; AY 206; AZ 207; BA 208; BB 209; BC 210; BD 211; BE 212; BF 213; BG 214; BH 215, 216, 217, 218; BI 219; BJ 220, 221, 222; BK 223; BL 224, 225; BM 226, 227; BN 228; BO 229, 230, 231; BP 232, 233; BQ 224, 225, 226; BR 237; BS 238, 239; BT 240; BU 241, 242; BV 243; BW 244; BX 144; BY 59; BZ 117; CA 79; CB 245; CC 130; CD 126; CE 128; CF 41; CG 246; CH 137.