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The clearance pathway (Intramural Peri‐Arterial Drainage, IPAD). (1) IPAD begins with the entry of interstitial fluid ISF and solutes from the brain parenchyma into basement membranes in the walls of cerebral capillaries. (2) Fluid and solutes then drain into the IPAD pathways in the basement membranes that surround smooth muscle cells in the tunica media of arteries. (3) It is along the IPAD pathway that fluid and solutes are eliminated from the brain through drainage to lymph nodes.
