TABLE 1.

Data inclusion and exclusion criteria

Data inclusion criteria
1	For the characterization of number of the synapses per connections, we used published values from anatomical studies employing electron and light microscopy; in rat CA1 slices.
2	For the validation of our axo‐dendritic innervation patterns, we used figures from published studies with biocytin‐filled pairs; under light microscopy; in rat CA1 slices.
3	For the characterization of synaptic physiology, we prioritized data from: Paired recordings from identified m‐types; in rat CA1 slices; at 2 mM [Ca2+]o; and 34°C; with reported holding/SS potential; and reported LJP or recording solutions.
4	For the parametrization the decay time constant of single PSCs, we used published decay time constant fits (independent of the model, e.g., single vs. biexponential fit).
5	For fitting the TM model, we used average raw PSC traces as well as published peak PSC amplitudes; with 10 spikes at different frequencies plus a recovery spike.
6	For the validation of the TM model, we used published fits from the neocortex (Markram et al., 2015) in order to compare USE, D, F values of the corresponding pathways.
7	For the estimation of the NRRP, we used raw PSC traces (all trials) to estimate the CV of the first peak PSC amplitude as well as published NRRP estimates.
8	For the calibration of peak synaptic conductance amplitudes, we used published peak PSP amplitudes (see Supplementary Table S2).
9	For the validation of the peak synaptic conductances, we used single‐receptor conductance and receptor number estimates.
Data exclusion criteria
10	In the case of multiple reports of a single parameter or reference data, we prioritized publications which were already used for other parameters and excluded the others (see, e.g., (Pawelzik, Hughes, & Thomson, 2002) in Supplementary Table S2).
11	When we had access to individual PSP amplitudes beyond the usually reported mean ± SD, we excluded outliers and used the updated mean ± SD as target PSP amplitude (see Supplementary Table S5).