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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Food Chem Toxicol. 2020 Feb 8;139:111186. doi: 10.1016/j.fct.2020.111186

Figure 4. Predicted activation of VEGF signaling after both APAP300 and PHX.

Figure 4.

Ingenuity Pathway Analysis (IPA) of microarray data showing predicted activation of VEGF signaling at 48 hr (vs 0 hr) after (A) APAP 300 and (B) PHX, based on downstream gene expression profile. Positive z-score (absolute z-score > 2 considered as significant) represents predicted activation of upstream regulator based on expression profile of downstream genes. p-values signifies extent of overlap between set of downstream target genes of a upstream regulator in dataset compared to all known downstream target genes of that upstream regulator in the reference genome. (red shapes: upregulated genes; green shapes: downregulated genes with intensity of color reflecting extent of upregulation or downregulation; orange center shape: predicted activation)