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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Food Chem Toxicol. 2020 Feb 8;139:111186. doi: 10.1016/j.fct.2020.111186

Figure 5. Predicted inhibition of Let-7 miRNA after both APAP300 and PHX.

Figure 5.

Ingenuity Pathway Analysis (IPA) of microarray data showing predicted inhibition of Let-7 at 48 hr (vs 0 hr) after (A) APAP 300 and (B) PHX, based on downstream gene expression profile. Most of the downstream genes which are known to be inhibited by Let 7 miRNA are induced after both APAP and Phx. Negative z-score (absolute z-score > 2 considered as significant) represents predicted inhibition of upstream regulator based on expression profile of downstream genes. p-values signifies extent of overlap between set of downstream target genes of a upstream regulator in dataset compared to all known downstream target genes of that upstream regulator in the reference genome. (red shapes: upregulated genes; green shapes: downregulated genes with intensity of color reflecting extent of upregulation or downregulation; blue center shape: predicted inhibition)