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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Food Chem Toxicol. 2020 Feb 8;139:111186. doi: 10.1016/j.fct.2020.111186

Figure 6. Temporal differences in activation of IL6 signaling after APAP300 and PHX.

Figure 6.

Ingenuity Pathway Analysis (IPA) of microarray data showing (A) predicted inhibition of IL6 signaling at 3 hr and (B) activation at 24 hr after APAP 300 compared to PHX, based on downstream gene expression profile. As shown in Figure 2, IL6 was activated as early as 3 hr after PHX, while activation was delayed (starting from 12 hr) after APAP300. Positive or negative z-score (absolute z-score > 2 considered as significant) represents predicted activation or inhibition of upstream regulator based on expression profile of downstream genes. p-values signifies extent of overlap between set of downstream target genes of a upstream regulator in dataset compared to all known downstream target genes of that upstream regulator in the reference genome. (red shapes: upregulated genes; green shapes: downregulated genes with intensity of color reflecting extent of upregulation or downregulation; blue center shape: predicted inhibition; orange center shape: predicted activation)