Fig. 1.

Neuropathological findings of COVID-19. (A) Coronal brain slice from a 55 year old man who died from COVID-19 contains a calcified nodule (arrow) in the right globus pallidus, but is otherwise unremarkable. (B) Hematoxylin and eosin stained section of hippocampus shows scattered hypereosinophilic neurons indicative of acute hypoxic injury. (C) Hematoxylin and eosin stained section shows extravasated red blood cells suggestive of microhemorrhage (deep pink). (D) CD45 immunostaining (brown) highlights a small collection of perivascular immune cells. (E) CD45 immunostaining (brown) also highlights numerous resident immune cells of the brain parenchyma (microglia). (F) In comparison to panel E, a patient without COVID-19 shows minimal CD45 immunostaining (brown). (G) SARS-CoV-2 nucleocapsid immunohistochemistry (brown) shows a cytoplasmic staining pattern in respiratory epithelial cells of the trachea. (H) Transmission electron micrograph of SARS-CoV-2 from cultured cells shows spherical extracellular viral particles (arrows). Images B-F taken at 200x magnification, G at 400x magnification, and are each from a different patient. Image H is from the Centers for Disease Control and Prevents Public Health Image Library, courtesy of Courtesy Cynthia S. Goldsmith and A. Tamin.