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. 2020 Nov 23;39:256. doi: 10.1186/s13046-020-01772-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Bioinformatics analysis revealed genes that are potentially associated to radioresistance in LUAD. a Previous studied showed change of transcriptome profiles of radiation-resistant A549 cells under irradiation. This study performed an enrichment analysis of the significantly changed mRNA (|log2 fold change| > 1.0 and P < 0.05) using a functional enrichment analysis tool, FunRich 3.1.3 (http://funrich.org/index.html). b Previous studies also manifested that the m6A level of thousands of mRNA was affected by METTL3. This study performed an intersection analysis between the changed mRNA and METTL3-regulated mRNA. c TCGA dataset (http://starbase.sysu.edu.cn/index.php) showing expression levels of TRIAP1, DRG1, SEMA3A and VANGL1 in LUAD and normal lung tissues. d Starbase (http://starbase.sysu.edu.cn/index.php) and (E) Gepia (http://gepia.cancer-pku.cn/) showing the survival time and percentage of survival in LUAD patients with high or low TRIAP1, DRG1, SEMA3A and VANGL1 levels