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. 2020 Nov 23;39:256. doi: 10.1186/s13046-020-01772-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — METTL3, IGF2BP2/3 and miR-29b-3p also regulated LUAD radioresistance. Before exposing to irradiation, A549 and H1299 cells were transfected with miR-29b-3p mimics, METTL3 expression vector, METTL3 expression vector + IGF2BP2 shRNA, METTL3 expression vector + IGF2BP3 shRNA, or METTL3 expression vector + miR-29b-3p mimics. After irradiation, cell viability (a), the percentage of apoptotic cells (b) and invasion capacity (c) were evaluated. Ba: the charts from flow cytometry measurements; Bb: the bar charts of the percentage of apoptotic cells. Ca: the charts from cell invasion assay; Cb: the bar charts of the number of invading cells.*P < 0.05, **P < 0.01 and ***P < 0.001 vs. control group. One-way analysis of variance (ANOVA) with post-hoc Dunnett’s testing (n = 3)