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. 2020 Nov 25;39:261. doi: 10.1186/s13046-020-01773-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Distinct peptide modification states detected in DIPG tumor tissue. a Distinct combinations of modification states are observed on ten peptides in H3.3K27M mutant tumor tissue (n = 9) relative to H3.3K27 wild-type (WT) tissue (n = 3).* p < 0.05 compared to H3.3K27 WT group, Independent-sample t test, two-tailed. b-f Scatter plots showing the correlation between relative abundance of H3.1K27me1K36me2/me3, H4K5un K8acK12unK16ac, and H3.3K27MK36me2/3 peptides with the H3.3K27M peptide in DIPG tumor tissue (Pearson Correlation = 0.72, −0.79, 0.95, 0.99, and 0.97, respectively, all p < 0.01. Pearson Correlation, two-tailed, n = 12). g Relative abundance of H3.3K27MK36 peptide modification states in DIPG tumor tissue reveals K36me2 as the most abundant co-occurring peptide with H3.3K27M mutation peptide. * p < 0.05 compared to all the other groups (Tukey HSD, Post Hoc Tests, one way ANOVA, n = 9)