Table 5.
Effects of bromodomain inhibition with JQ1 on relative histone peptide abundance in NHA cells
| Histone code | Mean | Fold (JQ1/DMSO) | p_NHA | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | DMSO 24 h | DMSO 48 h | JQ1 24 h | JQ1 48 h | 24 h | 48 h | 24 h | 48 h | |
| H2AK5ac | 8.8 | 6.4 | 6.2 | 3.9 | 4.7 | 0.6 | 0.8 | 0.06 | < 0.05 |
| H3.1K27me3 | 19.7 | 18.3 | 18.2 | 22.0 | 24.0 | 1.2 | 1.3 | < 0.05 | < 0.05 |
| H3.1K36me1 | 14.6 | 14.5 | 13.9 | 16.4 | 15.9 | 1.1 | 1.1 | 0.21 | < 0.05 |
| H3.1K36me2 | 27.6 | 29.2 | 29.7 | 25.6 | 24.1 | 0.9 | 0.8 | 0.08 | < 0.05 |
| H3.3K36me1 | 8.7 | 9.2 | 8.5 | 10.6 | 11.0 | 1.2 | 1.3 | 0.17 | < 0.01 |
| H3.3K36ac | 8.5 | 8.8 | 10.0 | 6.3 | 7.1 | 0.7 | 0.7 | < 0.05 | < 0.01 |
| H3K18ac | 10.1 | 8.1 | 7.3 | 6.2 | 6.0 | 0.8 | 0.8 | 0.10 | < 0.05 |
| H3K79me1 | 14.3 | 15.2 | 16.1 | 17.5 | 14.2 | 1.2 | 0.9 | 0.27 | < 0.01 |
| H4K16ac | 28.5 | 27.5 | 27.3 | 26.2 | 30.8 | 1.0 | 1.1 | 0.66 | < 0.01 |