Table 2.

Relative gene expression of hepatic CPT-1, MCAD, LCAD and VLCAD in WT and HC-HMGB1-KO mice on LFD or HFD for 8 weeks

Gene	mRNA relative expression
	LFD			HFD
	WT	HC-HMGB1−/−	P value	WT	HC-HMGB1−/−	P value
β-oxidation
CPT-1α	1.24 ± 0.46	0.63 ± 0.24	0.069	0.98 ± 0.14	0.56 ± 0.18	0.010
MCAD	1.08 ± 0.35	0.57 ± 0.15	0.052	1.26 ± 0.20	0.48 ± 0.07	0.002
LCAD	0.97 ± 0.14	0.91 ± 0.07	0.450	0.99 ± 0.14	0.52 ± 0.14	0.003
VLCAD	1.01 ± 0.34	0.49 ± 0.27	0.054	0.91 ± 0.021	0.41 ± 0.0	< 0.001
Lipogenesis
FAS	0.96 ± 0.05	0.87 ± 0.32	0.610	0.93 ± 0.41	0.78 ± 0.18	0.550
PPAR-γ	0.96 ± 0.04	0.70 ± 0.24	0.120	1.87 ± 0.66	1.69 ± 0.17	0.630
SCD-1	1.01 ± 0.29	1.47 ± 0.39	0.110	0.80 ± 0.10	2.32 ± 0.98	0.053
Adipophilin	0.89 ± 0.21	0.41 ± 0.38	0.091	2.78 ± 1.99	0.44 ± 0.49	0.096
Lipolysis
LPL	1.18 ± 0.25	0.28 ± 0.30	0.004	0.16 ± 0.15	0.40 ± 0.17	0.079
SREBP1	1.42 ± 0.21	1.16 ± 0.21	0.130	0.96 ± 0.29	0.62 ± 0.14	0.098

n = 4 for each group; data presented as mean ± SEM