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. 2020 Nov 25;39:260. doi: 10.1186/s13046-020-01745-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Circulating extracellular vesicular Wnt7b is correlated with aggressive clinical features and predicts a poor prognosis in CC. a Wnt7b expression in serum EVs from CC patients and controls. b Kaplan-Meier survival analysis of the OS and RFS rates of patients expressing high or low levels of extracellular vesicular Wnt7b. c A predictive nomogram model for the OS and RFS of CC patients according to serum extracellular vesicular Wnt7b and lymph node metastasis status. d The calibration curves of the nomogram for predicting 1-year and 3-year OS and RFS. The dashed line shows an ideal nomogram, and the solid line indicates the performance of the actual nomogram. The predicted observations matched the actual observations.