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. 2020 Nov 25;11:495. doi: 10.1186/s13287-020-01986-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Immunogenicity of RPE cells or LbL-RPE cells at 5 and 21 weeks after transplantation. a–d Photomicrographs showed the labeling of RCS rats’ retinal sections at 5 and 21 weeks after transplantation. Anti-Iba1/CD3 antibody (green); many Iba1⁺ cells (arrow) invaded the INL/ONL after RPE transplants, but were poorly labeled after LbL-RPE transplants (RPE and LbL-RPE cells were pre-labeled with Dil (red)). There were numerous CD3⁺ cells (arrow) which infiltrated in the RPE retinas. CD3⁺ cells were very sparse in LbL-RPE transplants. Scale bars 20 μm. e, f The number of positive Iba1⁺ and CD3⁺ cells around the transplanted retinas at 5 and 21 weeks after transplantation (mean ± SEM; ****p < 0.0001; ***p < 0.001; *p < 0.05; n = 8)