. 2020 Nov 24;19:198. doi: 10.1186/s12933-020-01176-4

Table 6.

Effect of metformin on arrhythmias: ongoing clinical trials

Model	Status	Type of study/No. of patients/FU	Intervention	Primary outcome	References
Patients with paroxysmal or persistent AF with CIED	Recruiting	Phase 4 Randomized clinical trial/270 patients/2 years	- Metformin 750 mg twice daily × 2 years - Lifestyle/risk factor modification	Change in %AF burden at 1 year	[95]
Patients with AF who underwent AF catheter ablation	Terminated	Phase 2 Randomized clinical trial/6 patients/6 months	- Metformin 1000 mg twice daily	Number of patients who maintain sinus rhythm	[96]

Model

Status

Type of study/No. of patients/FU

Intervention

Primary outcome

References

Patients with paroxysmal or persistent AF with CIED

Recruiting

Phase 4 Randomized clinical trial/270 patients/2 years

- Metformin 750 mg twice daily × 2 years

- Lifestyle/risk factor modification

Change in %AF burden at 1 year

Patients with AF who underwent AF catheter ablation

Terminated

Phase 2 Randomized clinical trial/6 patients/6 months

- Metformin 1000 mg twice daily

Number of patients who maintain sinus rhythm

AF atrial fibrillation, CIED cardiovascular implantable electronic device