Table 4.

Overview studies regarding clinical criteria

Author	Patients	Collective	Primary outcome	Suspected infection	SIRS	SOFA	qSOFA
Lo et al. [20]	n = 380,920	Mixed	Mortality	No	n.a.	n.a.	0.68
Kovach et al. [21]	n = 10,981	ED; ICU; mixed	Mortality	Yes	0.79	0.90	0.84
Seymour et al. [7]	n = 7932	ICU; mixed	Mortality	Yes	0.64	0.74	0.66
Zhang et al. [23]	n = 5109	Surgical ICU	Mortality	No	0.95	0.96	0.95
Falcao et al. [31]	n = 3008	Surgical ICU	Mortality	No	n.a.	0.742	n.a.
Gando et al. [25]	n = 1045	ED; mixed	Infection	Yes	0.647	n.a.	0.582
Basile-Filho et al. [32]	n = 847	Surgical ICU	Mortality	No	n.a.	0.791	n.a.
Mungan et al. [33]	n = 233	Surgical ICU	Mortality	No	n.a.	0.631	n.a.
Innocenti et al. [34]	n = 135	ED-HDU; mixed	Mortality	Yes	n.a.	0.80	n.a.

ICU Intensive care unit, ED Emergency department, HDU High-dependency unit, qSOFA Quick Sequential Organ Failure Assessment, SIRS Systemic inflammatory response syndrome, SOFA Sequential organ failure assessment