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. 2020 Nov 25;21:81. doi: 10.1186/s40360-020-00458-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Effects of continentalic acid (10, 50 and 100 mg/kg) on LPS-induced mortality (a), lung W/D ratio (b) and temperature changes (c) in mice following LPS-induced lung injury. The survival rate was analysed at different time interval such as 0, 3, 6, 9, 12, 15, 18, 21 and 24 h following LPS-induced acute lung injury and the effect of the continentalic acid was assessed on the LPS-induced acute lung injury. The continentalic acid dose dependently improved the survival rate and the dose of the 100 mg/kg showed maximum protection. Similarly, the weight to dry ratio of the lung was assessed by dividing the wet weight of the lung on the dry weight. Furthermore, the temperature changes were determined in all the treated groups before the induction of the LPS-induced lung injury and 24 h after the LPS administration. The continentalic acid showed significant improvement in the survival rate, lung W/D ratio and temperature changes. All the data were expressed as mean (n = 8) ± SD. ^###p < 0.001 compared to control group; ^*p < 0.05, ^**p < 0.01 and ^***p < 0.001 compared to LPS-treated group