Fig. 5. Structural comparisons of EBV gHgL–LBD to ephrin-A1–LBD and to EBV gHgL–gp42–E1D1.

a Superimposition of the EBV gHgL–LBD with the ephrin-A1–LBD (PDB: 3HEI). The interface where ephrin-A1²¹ inserts into the LBD channel is shown. Details of the contact residues at the LBD-binding interface are shown. Ephrin-A1-binding residues are colored violet, EBV gHgL-binding residues are colored orange, and overlapping binding residues are colored red. b Superimposition of EBV gHgL–LBD and EBV gHgL–gp42–E1D1 (PDB: 5T1D). EBV gHgL–gp42–E1D1¹² is colored gray. Details of the contact residues at the binding interface of EBV gHgL are shown. LBD-binding residues are colored yellow, E1D1-binding residues are colored green, and overlapping binding residues are colored red.