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. 2020 Nov 24;10:407. doi: 10.1038/s41398-020-01087-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a NSC line morphology of E492K mutant line (323) and control line (770) with red arrows indicating neurite growth. NSC line 770 also appears to have denser growth of cells and more neurite outgrowth. b Cell proliferation measured by absorbance of formazan in NSC lines. (n = 3). c Proportion of neural stem cells in a given field with at least one neurite outgrowth with or without NGF treatment. Control cell line (770) has a significantly higher (One way ANOVA; n = 12, **p < 0.01) proportion of cells with neurite outgrowth when treated with NGF. d NTRK1 expression of NSCs. NTRK1 expression of the control cell line, 770, is significantly different (Independent T-test; **p < 0.01) when compared to the mutant cell line, 323.