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. Author manuscript; available in PMC: 2020 Nov 25.
Published in final edited form as: J Med Chem. 2020 Aug 21;63(17):9212–9227. doi: 10.1021/acs.jmedchem.0c00302

Figure 4.

Figure 4.

Comparison of structural features of mPTPB with other human PTPs. (A) Electrostatic potential is calculated using APBS and is mapped onto the molecular surface of the mPTPB structure from the PDB code: 2OZ5 (using PyMOL).64 The active site of mPTPB is highly positively charged (blue region). (B) Comparison of P-loop residues of mPTPB with various other members of the PTP family. (C) Overlay of P-loop residues of mPTPB and human PTP1B. mPTPB residues were colored in red (PDB code: 2OZ5) and human PTP1B residues were colored in green (PDB code: 1XBO).