Table 4.
Specificity of 4g, 4k, and 4t for mPTPB over a Large Panel of PTPs
| PTP | 4g IC50 (∝M) | 4k IC50 (∝M) | 4t IC50 (∝M) |
|---|---|---|---|
| mPTPB | 0.160 | 0.015 | 0.0064 |
| mPTPA | >50 | >50 | >30 |
| SHP1 | 38.5 | >50 | >30 |
| SHP2 | 47.5 | >50 | >30 |
| PTP1B | 45.1 | >50 | >30 |
| TC-PTP | >50 | >50 | >30 |
| LYP | >50 | >50 | >30 |
| HePTP | >50 | >50 | >30 |
| FAP-1 | >50 | >30 | >30 |
| DEP-1 | >50 | >30 | >30 |
| Laforin | >50 | >30 | >30 |
| PTP-MEG2 | >50 | >30 | >30 |
| MKP3 | >50 | >30 | >30 |
| MKP5 | >50 | >30 | >30 |
| YopH | >50 | >30 | >30 |
| LMPTP-1 | 34.5 | >30 | >30 |
| PTP-PEST | >50 | >30 | >30 |
| CD45 | >50 | >30 | >30 |
| CDC14A | >50 | >30 | >30 |
| STEP | >50 | >30 | >30 |
| VHR | >50 | >30 | >30 |
| PTPσ | >50 | >30 | >30 |
| PTPα | >50 | >30 | >30 |
| PTPβ | 11.5 | >30 | >30 |
| PTP∝ | >50 | >30 | >30 |
| PTPγ | >50 | >30 | >30 |
| PTPε | >50 | >30 | >30 |