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. 2020 Nov 25;15(11):e0242748. doi: 10.1371/journal.pone.0242748

Table 4. Univariate and multivariate analyses of pre-S deletion regions for recurrence-free survival in 75 HBV-related HCC patients.

Characteristics Univariate Analysis Multivariate Analysis
HR 95% CI P value HR 95% CI P value
Age (years) (>50 vs. ≤50) 0.951 0.532–1.700 0.8666
Gender (men vs. women) 1.043 0.414–2.627 0.9284
Smoking (yes vs. no) 0.886 0.503–1.560 0.6750
Alcohol (yes vs. no) 0.884 0.494–1.580 0.6773
HBsAg (positive vs. negative)a
HBeAg (positive vs. negative)b 1.234 0.523–2.910 0.6307
HBV genotype (B vs. C) 0.583 0.304–1.117 0.1040
HBV DNA (copies/mL) (>1×104 vs. ≤1×104)c 1.645 0.934–2.895 0.0846
Albumin (g/dL) (>3.8 vs. ≤3.8) 0.551 0.288–1.092 0.0585
AST (U/L) (>34 vs. ≤34) 0.865 0.444–1.684 0.6691
ALT (U/L) (>40 vs. ≤40) 0.797 0.456–1.394 0.4267
AFP (ng/mL) (>400 vs. ≤400) 1.305 0.745–2.285 0.3524
Tumor size (cm) (>5 vs. ≤5) 1.490 0.863–2.572 0.1525
Tumor encapsulation (yes vs. no)d 0.901 0.474–1.713 0.7508
Lymph node involvement (yes vs. no) 0.333 0.104–1.071 0.0652
Portal vein thrombosis (yes vs. no) 1.668 0.600–4.633 0.3264
Vascular invasion (yes vs. no) 1.677 0.962–2.924 0.0681
Distant metastasis (yes vs. no) 2.259 0.999–5.101 0.0502
Steatosis grade (2/3 vs. 0/1)e 3.473 0.418–28.879 0.2493
Metavir inflammation score (2/3 vs. 0/1)f 0.731 0.256–2.088 0.5583
Ishak fibrosis score (4/5/6 vs. 0/1/2/3)g 1.261 0.670–2.373 0.4714
Child-Pugh cirrhosis score (B/C vs. A) 2.189 1.195–4.013 0.0112* 2.065 1.086–3.927 0.0271*
CLIP score (4/5/6 vs. 0/1/2/3) 2.426 0.328–17.911 0.3850
BCLC stage (C/D vs. A/B) 1.927 0.867–4.284 0.1077
AJCC TNM stage (IIIA/IIIB/IIIC/IVA/IVB vs. I/II) 4.048 2.123–7.719 <0.0001*** 3.411 1.710–6.804 0.0005***
Antiviral therapy after surgery (yes vs. no) 1.176 0.674–2.051 0.5684
Pre-S1 del (nt 2854–2970) (yes vs. no) 1.166 0.525–2.593 0.7059
Pre-S1 del (nt 2855–2872) (yes vs. no) 1.293 0.465–3.598 0.6221
Pre-S2 del (nt 1–54) (yes vs. no) 2.279 1.260–4.122 0.0065** 2.392 1.297–4.410 0.0052**
Pre-S1+pre-S2 del (nt 2855–2872, 1–54) (yes vs. no) 1.614 0.827–3.151 0.1604

aThere were no patients negative for HBsAg for analysis.

bOnly 71 patients with available data were analyzed.

cOnly 74 patients with available data were analyzed.

dOnly 62 patients with available data were analyzed.

eOnly 25 patients with available data were analyzed.

fOnly 44 patients with available data were analyzed.

gOnly 56 patients with available data were analyzed.

*, P value<0.05

**, P value<0.01

***, P value<0.001.

Abbreviations: HR, hazard ratio; CI, confidence interval; del, deletion; vs., versus.