Table 1. Top ten genes upregulated by 20% IQOS CSE at 6 h after exposure.

Gene Symbol	Description	Fold Change 10% IQOS vs Control	Fold Change 20% IQOS vs Control
Lhx5	Rattus norvegicus LIM homeobox 5 (Lhx5), mRNA [NM_139036]	3.42	221.57
Gsta3	Rattus norvegicus glutathione S-transferase alpha 3 (Gsta3), transcript variant 1, mRNA [NM_001009920]	3.19	10.67
ZSCAN29	zinc finger and SCAN domain containing 29 [Source:RGD Symbol;Acc:1559150] [ENSRNOT00000035889]	7.24	8.13
Hmox1	Rattus norvegicus heme oxygenase 1 (Hmox1), mRNA [NM_012580]	3.01	7.89
RGD1563231	similar to immunoglobulin kappa-chain VK-1 [Source:RGD Symbol;Acc:1563231] [ENSRNOT00000074382]	7.09	7.19
Itgb3	Rattus norvegicus integrin subunit beta 3 (Itgb3), mRNA [NM_153720]	4.74	5.13
Glt1d1	glycosyltransferase 1 domain containing 1 [Source:RGD Symbol;Acc:1304896] [ENSRNOT00000064526]	6.05	5.10
Mest	Rattus norvegicus mesoderm specific transcript (Mest), mRNA [NM_001009617]	3.25	4.75
Prl8a7	Rattus norvegicus prolactin family 8, subfamily a, member 7 (Prl8a7), mRNA [NM_022537]	3.56	4.05
Best3	Rattus norvegicus bestrophin 3 (Best3), mRNA [NM_001191783]	4.02	3.83