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CircRNA0001859 was downregulated in serum obtained from COPD, AECOPD and lung cancer with COPD patients and mice serum treated by CS/NNK alone or CS + NNK. a IL-6 and b TNF-α were evaluated using ELISA (n = 6). qRT-PCR was performed to evaluate the expression of circRNA0001859 in the blood of patients (c) or mice (d) (n = 6). *p < 0.05. Three independent biological repeats were carried out for each analysis
