TABLE 2.
Antimicrobial activities of hydroxylalkylquinoline analogs
| Quinolone familya | Carbon chain | [M + H]+ | MIC (μg/ml)b
|
|
|---|---|---|---|---|
| B. subtilis 168 | S. aureus Newman | |||
| HMAQ | C9:2′ | 284 | 50 | 25 |
| HMAQ-NO | C9:2′ | 300 | 0.75 | 25 |
| HAQ (HHQ) | C7 | 242 | >200 | >200 |
| HAQ-NO (HQNO) | C7 | 259 | 25 | 25 |
| HMAQ-NO | C8:2′ | 286 | 1.5 | 6.25 |
| HMAQ-NO | C7:2′ | 272 | 6.25 | 12.5 |
a
HMAQ with a C9 carbon chain (HMAQ-C9:2′) was purified as described in reference 21. HMAQ-NO congeners were synthesized as described in Materials and Methods and Piochon et al. (31). HAQ-NO with a C7 carbon chain (HQNO) and HAQ with a C7 carbon chain (HHQ) were purchased from commercial sources (Cayman Chemicals and Sigma Aldrich, respectively).
b
No activity of any of the compounds against Pseudomonas aeruginosa strain PA14 or Escherichia coli strain JM109 was observed up to 200 μg/ml. Results are the averages of three independent experiments. In all cases, the range was <5%.