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. 2020 Nov 17;2020:5925342. doi: 10.1155/2020/5925342

Figure 4.

Figure 4

Two-step luciferase assays confirmed HOTAIR may directly competing with GJA1 for miR-613 binding and positively regulate the Cx43 expression by sponging miR-613 as a ceRNA. (a) The binding site of miR-613 and GJA1 3′UTR. (b) GJA1 is a direct downstream target of miR-613; ∗P < 0.05, against the GJA1 WT + miR-613 NC group. (c) HOTAIR may directly competing with GJA1 for miR-613 binding; ∗P < 0.05, against the miR-613 NC group; #P < 0.05, against the miR-613 mimic group. miR: microRNA; HOTAIR: HOX transcript antisense RNA; UTR: untranslated regions; ceRNA: competitive endogenous RNA. The error bars mean standard deviation.