Table 4.
Subgroup analysis of the correlation between serum anion gap and 30-day all-cause mortality in critically ill patients with congestive heart failure.
| N | Serum anion gap (mmol/L) | P for interaction | |||
|---|---|---|---|---|---|
| <13 | ≥13, <16 | ≥16 | |||
| Liver diseases | 0.4454 | ||||
| No | 7121 | 1.0 (ref) | 1.45 (1.23, 1.70) | 2.56 (2.20, 2.97) | |
| Yes | 305 | 1.0 (ref) | 1.98 (0.97, 4.06) | 3.85 (2.04, 7.30) | |
| Renal failure | 0.0908 | ||||
| No | 5736 | 1.0 (ref) | 1.56 (1.31, 1.85) | 2.60 (2.21, 3.05) | |
| Yes | 1690 | 1.0 (ref) | 1.17 (0.79, 1.73) | 2.74 (1.94, 3.88) | |
| Atrial fibrillation | 0.1283 | ||||
| No | 4123 | 1.0 (ref) | 1.33 (1.07, 1.66) | 2.25 (1.84, 2.76) | |
| Yes | 3303 | 1.0 (ref) | 1.62 (1.30, 2.03) | 3.07 (2.50, 3.78) | |
| Stroke | 0.6586 | ||||
| No | 7035 | 1.0 (ref) | 1.43 (1.21, 1.68) | 2.63 (2.26, 3.06) | |
| Yes | 391 | 1.0 (ref) | 1.68 (1.01, 2.80) | 2.61 (1.59, 4.27) | |
| AMI | 0.4511 | ||||
| No | 6828 | 1.0 (ref) | 1.44 (1.23, 1.70) | 2.58 (2.22, 2.99) | |
| Yes | 598 | 1.0 (ref) | 2.14 (1.02, 4.51) | 3.90 (1.95, 7.83) | |
| VHD | 0.0653 | ||||
| No | 6736 | 1.0 (ref) | 1.52 (1.28, 1.80) | 2.78 (2.38, 3.24) | |
| Yes | 690 | 1.0 (ref) | 1.08 (0.69, 1.67) | 1.63 (1.08, 2.46) | |
| PCD | 0.0510 | ||||
| No | 7017 | 1.0 (ref) | 1.53 (1.30, 1.81) | 2.77 (2.38, 3.22) | |
| Yes | 409 | 1.0 (ref) | 0.88 (0.51, 1.51) | 1.43 (0.87, 2.34) | |
| HBP | 0.2921 | ||||
| No | 6008 | 1.0 (ref) | 1.49 (1.26, 1.76) | 2.59 (2.21, 3.03) | |
| Yes | 1418 | 1.0 (ref) | 1.61 (1.00, 2.58) | 3.52 (2.29, 5.42) | |
| Diabetes | 0.6109 | ||||
| No | 4773 | 1.0 (ref) | 1.41 (1.17, 1.69) | 2.56 (2.20, 2.97) | |
| Yes | 2653 | 1.0 (ref) | 1.61 (1.19, 2.17) | 2.76 (2.10, 3.62) | |
| Pneumonia | <0.0001 | ||||
| No | 5765 | 1.0 (ref) | 1.57 (1.29, 1.92) | 3.27 (2.73, 3.91) | |
| Yes | 1661 | 1.0 (ref) | 1.16 (0.89, 1.50) | 1.44 (1.13, 1.85) | |
| Respiratory failure | <0.0001 | ||||
| No | 5537 | 1.0 (ref) | 1.72 (1.37, 2.16) | 3.51 (2.85, 4.32) | |
| Yes | 1889 | 1.0 (ref) | 1.06 (0.85, 1.32) | 1.49 (1.22, 1.83) | |
| Malignancy | 0.0320 | ||||
| No | 7069 | 1.0 (ref) | 1.42 (1.20, 1.68) | 2.71 (2.33, 3.15) | |
| Yes | 357 | 1.0 (ref) | 1.69 (1.03, 2.77) | 1.84 (1.10, 3.07) | |
| Dialysis | 0.8370 | ||||
| No | 6811 | 1.0 (ref) | 1.45 (1.23, 1.70) | 2.51 (2.16, 2.92) | |
| Yes | 615 | 1.0 (ref) | 1.48 (0.69, 3.19) | 2.34 (1.18, 4.60) | |
| Vasopressor | 0.0736 | ||||
| No | 5704 | 1.0 (ref) | 1.46 (1.21, 1.77) | 2.33 (1.94, 2.80) | |
| Yes | 1722 | 1.0 (ref) | 1.62 (1.23, 2.13) | 3.15 (2.48, 4.01) | |
| Ventilation | 0.0088 | ||||
| No | 5018 | 1.0 (ref) | 1.57 (1.25, 1.98) | 2.95 (2.38, 3.65) | |
| Yes | 2408 | 1.0 (ref) | 1.22 (0.99, 1.52) | 1.89 (1.55, 2.30) | |
| SOFA | 0.3416 | ||||
| <4 | 2785 | 1.0 (ref) | 1.33 (1.00, 1.78) | 2.01 (1.50, 2.69) | |
| ≥4 | 4641 | 1.0 (ref) | 1.56 (1.30, 1.89) | 2.59 (2.19, 3.07) | |
| SAPSII | 0.8125 | ||||
| <39 | 3701 | 1.0 (ref) | 1.50 (1.13, 2.00) | 2.17 (1.62, 2.91) | |
| ≥39 | 3725 | 1.0 (ref) | 1.36 (1.12, 1.64) | 2.09 (1.77, 2.48) | |
Note: AMI: acute myocardial infarction; VHD: valvular heart diseases; PCD: pulmonary circulation diseases; HBP: hypertension; SOFA: stroke, and malignancy. Calculate the sequential organ failure assessment score; SAPSII: simplified acute physiology score II.