Table 4.

CARS and CSF findings at baseline and following antioxidant supplementation during 8 months (patients 1 and 2) and during 2 years (patient 3) among three children with severe infantile autism.

Patient	Age (yr)	5HIAA	HVA	Ratio	MTHF	Neo	Bio	Oxidative stress	CARS
(1) Baseline	3½	104↓	566	5.4↑	117	8.6	23	Lipid peroxides↑	42
Treatment	4½	160	436	2.7	100	18	37		34
(2) Baseline	4½	81↓	338	4.2↑	95	35	19	Lipid peroxides↑	45.5
Treatment	5.3	136	495	3.6↑	113	25	61	Lipid peroxides normal	43.5
(3) Baseline	17	25.6↓	92↓	3.6↑	82.7	9.5	10.7	Ox DNA↑, Trp↓	41
Treatment	19½	80	258	3.2	49	10	7↓
References (median and range)
	2–4 yr	202 (105–299)	603 (211–871)		63–111	9–30	10–30
	5–10 yr	133 (88–178)	523 (144–801)		41–117	9–20	10–30
	>16 yr	103 (66–141)	261 (115–488)		41–117	9–20	10–30

Ratio stands for the HVA/5HIAA ratio with a normal range 1.5–3.5. The sign ↑ denotes elevated value, and the sign ↓ denotes diminished value.