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Overview of ERK and AKT pathway on lymphangiogenesis. Both pathways influence different aspects of lymphatic remodeling upon activation of VEGFR-3, leading to downstream phosphorylation of signaling proteins (90). Crosstalk occurs across the pathways primarily as a means of negative regulation (95–97). Current therapies to inhibit these signaling pathways involve the sequestration of VEGFR and its ligands (98–100). Created with BioRender.com.
