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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Addict Biol. 2020 May 26:e12926. doi: 10.1111/adb.12926

Figure 1:

Figure 1:

A) Fentanyl infusions earned across all experimental phases (29 sessions). Each phase of the experiment is indicated above the corresponding session data. Data are shown for rats that completed all phases displayed (N=5–6/group). Phases (Acquisition, Demand, CON vs. INT) were analyzed separately. B-D) Comparison CON vs. INT phase: B) Average bout size across session for CON vs. INT groups. C) Average pause length across session for CON vs. INT groups. D) Latency to earn 1st infusion of session for CON vs. INT groups. E) Average number of presses during INT sessions across bins (sessions 19–27). Note scalloped responding between each pair of ON periods. A-D) “*” indicates main effect of group, 2-way RM ANOVA.