Figure 4. Effect of the serine protease inhibitor aprotinin on sodium retention in nephrotic nphs2^Δipod*plg^+/+ and nphs2^Δipod*plg^−/− mice.

(A-E) Course of urinary aprotinin concentration, proteinuria, urinary amidolytic activity, sodium excretion and body weight after end of induction of nephrotic syndrome (day 0). Groups were separated after pellet implantation at day 3.

(F) Plasma concentration of aldosterone before and on day 8 after induction of nephrotic syndrome and implantation of a placebo or aprotinin pellet on day 4. Due to the large scatter there is no significant difference, however, the results are in line with the increase under the nephrotic state (Fig. 2F) and normalization under aprotinin treatment as described previously ⁴.

Arithmetic means ± SEM, ^# indicates significant difference to baseline value, * indicates significant difference between genotypes, § indicated significant difference between placebo and aprotinin-treated nephrotic mice. U: uninduced; N+P: nephrotic + placebo; N+A: nephrotic + aprotinin.