Table 1: Sodium balance in nphs2Δipod *plg+/+ and nphs2Δipod *plg−/−miceduring various conditions.
uninduced control diet | uninduced low salt diet | nephrotic control diet | ||||
---|---|---|---|---|---|---|
nphs2Δipod*plg+/+ | nphs2Δipod*plg−/− | nphs2Δipod*plg+/+ | nphs2Δipod*plg−/− | nphs2Δipod*plg+/+ | nphs2Δipod*plg−/− | |
total Na+ intake, μmol24 h−1 | 290± 14 | 322 ±16 | 23 ± 1 # | 24 ± 1 # | 258 ± 15 | 304 ± 13 |
urinary Na+ excretion, μmol24 h−1 | 193 ± 16 | 229 ± 11 * | 18 ± 3 # | 16 ± 3 # | 15 ± 6# | 25 ± 7 # |
fecal Na+ excretion, μmol24 h−1 | 13 ± 1 | 19 ± 3 | 7 ± 1 | 13 ± 2 | 11 ± 2 | 21 ± 2 * |
Na+ balance, μmol24 h−1 | 84 ± 13 | 74 ±14 | −2 ± 3 # | −5 ± 3 # | 232 ± 18# | 258 ± 15# |
Arithmetic means ± SEM (n= 8–11 each).
significant difference compared to uninduced mice of the same genotype under a control diet,
significant difference between genotypes