Table 2:

List of compounds alone or as a co-treatment with other compounds undergo clinical trials

Compound name	Type of cancer	Clinical trial phase	Current status	Clinicaltrials.gov Identifier
Hydroxytyrosol	Breast cancer	Phase 2 and 3	Active, recruiting	NCT02068092
Resveratrol	Colon cancer Liver cancer Colorectal cancer	Phase 1 Phase 1 and 2 Phase 1	Completed Withdrawn Completed	NCT00256334 NCT02261844 NCT00433576
Curcumin	Prostate cancer Breast cancer Colorectal cancer	Phase 3 Phase 1 Phase 1	Active Recruiting Unkown	NCT03769766 NCT03980509 NCT00973869
Curcumin + Avastin/FOLFIRI	Colorectal cancer	Phase 2	Active, not recruiting	NCT02439385
Curcumin + 5- Fluorouracil	Metastatic colon cancer	Early phase 1	Active, not recruiting	NCT02724202
Berberine Hydrochloride	Colorectal Adenomas	Phase 2	Recruiting	NCT03281096
	Colorectal cancer patients with ulcerative colitis remission	Phase 1	Active, not recruiting	NCT02365480
Berberine + Gefitinib	Lung adenocarcinoma and EGFR mutation	Phase 2	Not yet recruiting	NCT03486496
EGCG	Colorectal cancer	Early phase 1	Recruiting	NCT02891538
	Patients with Lung cancer receiving radical radiotherapy	Phase 2	Recruiting	NCT02577393
Trabectedin (ET 743)	Prostate cancer Pancreatic cancer	Phase 2 Phase 2	Completed Completed	NCT00147212 NCT01339754
Trabectedin+Bevacizumab	Ovarian Epithelial cancer recurrent	Phase 2	Completed	NCT01735071
Plitidepsin + Sorafenib	Advanced solid tumors	Phase 1	Completed	NCT00788099
Plitidepsin + Gemcitabine	Lymphomas
Plitidepsin + Dexamethasone	Relapsed/Refractory Multiple Myeloma	Phase 3	Completed	NCT01102426
Oligo Fucoidan	Advanced Hepatocellular Carcinoma	Phase 2	Active	NCT04066660
Genistein + FOLFOX or FOLFOX- Avastin	Colon cancer Rectal cancer Colorectal cancer	Phase 1 and 2	Completed	NCT01985763
Genistein + Gemcitabine	Breast cancer	Phase 2	Completed	NCT00244933
Genistein	Prostate cancer	Phase 2	Recruiting	NCT02766478
Genistein + Decitabine	Non-Small Cell lung cancer	Phase 1 and Phase 2	Completed	NCT01628471