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. 2020 Nov 12;11:576214. doi: 10.3389/fpsyt.2020.576214

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Copyright © 2020 Chen and Mackie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Working memory. Working memory is impaired in adolescent mice chronically treated with THC. Success rate (out of 10 trials) during delayed-alternating T-maze training for 8 days of males (A) and females (B). Following 8 days of training, increasingly delayed internal times were tested in 5 trials for male (C) and female (D) mice. All data were analyzed by two-way ANOVA with Sidak's test and data are presented as (mean ± SEM). *P < 0.05; **P < 0.01 compared between naïve and THC groups. ***P < 0.001; ****P < 0.0001 comparison over time or between vehicle and THC groups. ^#P < 0.05; ^##P < 0.01; ^###P < 0.001; ^####P < 0.0001 compared between vehicle and THC groups (N = 4–14 per group).