Figure 5.

Elevated plus maze. Chronic adolescent Δ⁹-THC treatment doesn't affect mouse anxiety behaviors as measured on the elevated plus maze. Ratio of exploration time (A,B) and entries into (C,D) the open and closed arms, respectively, of the elevated plus maze as compared to vehicle treated animals. In contrast, naïve mice of both sexes showed less activity as measured by distance traveled, and male naïve mice showed fewer entries into the open arm, as compared to vehicle or Δ⁹-THC-treated mice (E). All data were analyzed by one-way ANOVA with Tukey's test, and data are presented as (mean ± SEM) *p < 0.05; ***p < 0.001 compared to naïve groups (N = 4–14 per group).