TABLE 3.
Incidence and median duration of all grade and grade III/IV neutropenia for different granulocyte colony‐stimulating factor (G‐CSF) and pegylated (Peg)‐G‐CSF dosing schedules and for no G‐CSF administration according high, moderate and low absolute neutrophil count (ANC) baseline simulated for 1000 virtual patients
| ANC baseline (× 109/L) | G‐CSF schedule | G‐CSF schedule duration (d) | For cycle 1 and cycle 2 | Median nadir after D1 (d) | Number of patients who did not receive C2 a | |||
|---|---|---|---|---|---|---|---|---|
| All grade neutropenia incidence (%) | Severe neutropenia incidence (%) | All grade neutropenia median duration (d) | Severe neutropenia median duration (d) | |||||
| 6.5 | No G‐CSF | / | 26.1 | 0.8 | 3.2 | 1.8 | 7,4 | 0 |
| 4.4 | No G‐CSF | / | 64.8 | 9.9 | 5.1 | 2.9 | 7.1 | 0 |
| Peg‐G‐CSF D4 | / | 38.1 | 7.6 | 1.2 | 0.6 | 4.0 | 3 | |
| Peg‐G‐CSF D5 | / | 54.4 | 13.9 | 1.3 | 1.0 | 5.0 | 3 | |
| Peg‐G‐CSF D6 | / | 67.4 | 21.1 | 1.9 | 1.6 | 6.0 | 11 | |
| Peg‐G‐CSF D7 | / | 69.8 | 18.9 | 2.7 | 2.2 | 7.0 | 11 | |
| G‐CSF D4 | 1 | 70.0 | 16.8 | 4.1 | 2.0 | 7.9 | 0 | |
| G‐CSF D4‐D5 | 2 | 61.1 | 14.2 | 4.0 | 1.9 | 8.8 | 1 | |
| G‐CSF D4‐D6 | 3 | 56.4 | 9.6 | 3.7 | 2.1 | 9.8 | 0 | |
| G‐CSF D4‐D8 | 5 | 53.0 | 10.2 | 3.5 | 2.0 | 11.9 | 8 | |
| G‐CSF D5‐D7 | 3 | 62.5 | 10.8 | 3.7 | 1.6 | 10.8 | 1 | |
| G‐CSF D5‐D9 | 5 | 65.3 | 12.4 | 2.7 | 1.3 | 12.8 | 51 | |
| G‐CSF D6‐D10 | 5 | 77.8 | 21.6 | 2.5 | 1.0 | 13.8 | 70 | |
| G‐CSF D7‐D11 | 5 | 83.2 | 27.9 | 3.1 | 2.3 | 7.0 | 32 | |
| 2.5 | No G‐CSF | / | 97.0 | 54.8 | 10.1 | 4.1 | 6.9 | 5 |
| Peg‐G‐CSF D4 | / | 83.6 | 31.9 | 3.7 | 1.0 | 4.0 | 16 | |
| Peg‐G‐CSF D5 | / | 92.2 | 51.3 | 3.4 | 1.1 | 5.0 | 13 | |
| Peg‐G‐CSF D6 | / | 95.1 | 58.9 | 3.8 | 1.8 | 6.0 | 13 | |
| Peg‐G‐CSF D7 | / | 97.0 | 63.8 | 4.5 | 2.6 | 6.9 | 18 | |
| G‐CSF D4‐D6 | 3 | 92.2 | 48.4 | 6.7 | 3.2 | 9.7 | 28 | |
| G‐CSF D4‐D8 | 5 | 90.9 | 45.4 | 5.8 | 2.7 | 11.7 | 197 | |
| G‐CSF D5‐D7 | 3 | 95.7 | 53.9 | 7.3 | 2.4 | 10.6 | 93 | |
| G‐CSF D5‐D9 | 5 | 95.8 | 60.4 | 5.3 | 1.9 | 12.6 | 334 | |
| G‐CSF D6‐D10 | 5 | 97.4 | 72.0 | 5.5 | 1.5 | 13.6 | 404 | |
| G‐CSF D7‐D11 | 5 | 99.3 | 76.3 | 6.2 | 2.6 | 7.0 | 282 | |
a
ANC baseline at C2 <1 × 109/L.