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Adjusted OR for each direct oral anticoagulant drug for prespecified endpoints as compared to VKAs. Adjusted for pattern of atrial fibrillation, age ≥75 years, female sex, arterial hypertension, diabetes mellitus, history of myocardial infarction/coronary heart disease, heart failure, history of stroke/transient ischemic attack, angiotensin converting enzyme inhibitor, angiotensin receptor blockers, β blockers, calcium channel antagonists, statins, antiplatelets
