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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: FASEB J. 2020 Jul 5;34(8):10762–10777. doi: 10.1096/fj.202000702RR

Figure 3. Loxl1−/− mice display dilated distal outflow veins but not arteries or capillaries.

Figure 3.

(A) Loxl1−/−, Loxl1+/− and Loxl1+/+ mouse anterior segments were immunostained with antibody against CD31, and imaged using confocal microscopy at 20 × magnification. (B) Measurements of distal outflow vessels indicate a significant increase in distal vessel width in Loxl1−/− mice when compared to Loxl1+/+ eyes (****p<0.0001). There was no difference between Loxl1+/+ and Loxl1+/− eyes. The central line in the scatter plot indicates the mean (n=6 eyes from 4 mice for both Loxl1+/+ and Loxl1+/−, n=6 eyes from 5 mice for Loxl1−/−) A, arteries; V, veins; C, capillaries (scale bar=100μm).