The coronary conductance, normalized to weight of myocardium perfused, was not different between groups at resting “baseline” flow, or maximal hyperemia on A) day 0, or B) day 7 of IGF-1 or vehicle treatment. C) Coronary reserve was reduced within the IGF-1 group between days 0 and 7. Control n=12, IGF-1 n=8. Data were analyzed by 2-way repeated measures ANOVA followed, if justified, by the Holm-Šidák multiple comparisons test (P<0.05). Different from *same-group day 0. Data are shown as mean ± SD.