Table 2.

Daily study blood gas and chemistry values.

	Day of Study		P-value
	0	7	Interaction	Day	Group
Fetal arterial blood
pH
Control	7.341 ± 0.031	7.321 ± 0.040	NS	NS 0.070	NS
IGF-1	7.338 ± 0.017	7.324 ± 0.025
CO2 partial pressure (mmHg)
Control	51.9 ± 3.4	51.8 ± 2.9	0.002	-	-
IGF-1	51.0 ± 2.3	54.1 ± 2.0†
O2 partial pressure (mmHg)
Control	19.6 ± 3.1	19.6 ± 2.0	0.026	-	-
IGF-1	20.2 ± 1.7	17.0 ± 2.4†
Total Hemoglobin (g dL−1)
Control	10.1 ± 1.6	10.4 ± 2.3	0.042	-	-
IGF-1	10.6 ± 1.4	9.6 ± 1.9
O2 content (mL dL−1)
Control	7.2 ± 1.1	7.1 ± 1.5	0.013	-	-
IGF-1	7.8 ± 1.4	5.3 ± 1.7*†
Glucose (mM)
Control	0.9 ± 0.2	0.9 ± 0.2	0.011	-	-
IGF-1	1.0 ± 0.3	0.7 ± 0.2†
Lactate (mM)
Control	1.5 ± 0.3	1.5 ± 0.3	NS	NS	NS
IGF-1	1.5 ± 0.3	2.7 ± 2.8
Hematocrit (%)
Control	34.6 ± 6.0	35.2 ± 7.5	NS 0.07	NS	NS
IGF-1	36.4 ± 4.9	33.2 ± 6.8
Fetal coronary sinus blood
pH
Control	7.322 ± 0.035	7.292 ± 0.052	NS	NS	NS
IGF-1	7.308 ± 0.017	7.304 ± 0.025
CO2 partial pressure (mmHg)
Control	55.8 ± 2.4	58.0 ± 3.8	NS	NS 0.061	NS 0.054
IGF-1	58.7 ± 2.6	60.0 ± 2.2
O2 partial pressure (mmHg)
Control	12.9 ± 2.0	11.7 ± 1.4	NS	0.015	NS
IGF-1	11.7 ± 1.9	10.6 ± 2.2
O2 content (mL dL−1)
Control	3.5 ± 1.0	2.8 ± 1.1	NS	0.022	NS
IGF-1	2.9 ± 1.1	2.2 ± 0.9
Glucose (mM)
Control	0.8 ± 0.2	0.6 ± 0.2	NS	0.001	NS
IGF-1	0.8 ± 0.3	0.5 ± 0.2
Lactate (mM)
Control	1.3 ± 0.2	1.2 ± 0.5	NS	NS	NS
IGF-1	1.0 ± 0.3	2.5 ± 3.1

Arterial values, Control n=12 (except O₂ saturation n=10) and IGF-1-treated n=8. Coronary sinus values, Control n=9 and IGF-1 n=8 on day 0, and both groups n=7 on day 7. Arterial values analyzed by 2-way repeated measures ANOVA. Coronary sinus values analyzed by mixed-effects analysis. If justified, further analysis was by the Holm-Šidák test.

^*Different within-day from Control

^†within-group from day 0 (P<0.05). Data shown as mean ± SD.