Table 1.
Bone Parameters in Eif2ak4−/− Mice
| 4-month-old | ||
|---|---|---|
| wild type | Eif2ak4−/− | |
| Male (n) | 6 | 6 |
| Weight (g) | 24.4 ± 0.7 | 24.1 ± 1.7 |
| BV/TV | 0.122 ± 0.053 | 0.065 ± 0.048a |
| Tb.N (1/mm) | 2.94 ± 0.10 | 2.10 ± 0.47a |
| Tb.Th (mm) | 0.074 ± 0.009 | 0.062 ± 0.011a |
| Tb.Sp (mm) | 0.35 ± 0.01 | 0.51 ± 0.12a |
| BMD (mg HA/ccm) | 228 ± 23 | 183 ± 33a |
| Ct.BV/TV | 0.44 ± 0.04 | 0.43 ± 0.005 |
| Ct.Th (mm) | 0.18 ± 0.002 | 0.17 ± 0.001a |
| T.Ar (mm) | 1.89 ± 0.17 | 1.74 ± 0.08 |
| TMD (mg HA/ccm) | 1073 ± 38 | 1078 ± 14 |
| Female (n) | 10 | 10 |
| Weight (g) | 20.2 ± 1.5 | 19.6 ± 1.1 |
| BV/TV | 0.027 ± 0.018 | 0.015 ± 0.006a |
| Tb.N (1/mm) | 1.22 ± 0.08 | 1.08 ± 0.15 |
| Tb.Th (mm) | 0.068 ± 0.013 | 0.051 ± 0.008a |
| Tb.Sp (mm) | 0.83 ± 0.06 | 1.03 ± 0.14a |
| BMD (mg HA/ccm) | 140 ± 17 | 126 ± 11a |
| Ct.BV/TV | 0.45 ± 0.007 | 0.44 ± 0.0.016 |
| Ct.Th (mm) | 0.18 ±0.009 | 0.17 ± 0.012a |
| T.Ar (mm) | 1.67 ±0.14 | 1.58 ± 0.10a |
| TMD (mg HA/ccm) | 1093 ± 18 | 1081 ± 13 |
| Serum chemistry (n =5) (male) | ||
| P1NP (ng/mL) | 516.24 ± 167.16 | 287.47 ± 153.333 |
| CTX-I (ng/mL) | 29.05 ± 9.97 | 26.17 ± 10.58 |
| Dynamic histomorphometry (n = 5) (male) | ||
| MAR (μm2/d) | 0.72 ± 0.06 | 0.44 ± 0.03a |
| MS/BS (%) | 37.2 ± 5.0 | 25.7 ± 2.6a |
| BFR (μm3/μm2/d) | 0.27 ± 0.04 | 0.11 ± 0.01a |
| Static histomorphometry (n = 7) (male) | ||
| Ob.N/BS | 14.0 ± 0.3 | 7.4 ± 0.8a |
BV/TV = bone volume/tissue volume; Tb.N = trabecular number; Tb.Th = trabecular thickness; Tb.Sp = trabecular separation; BMD = bone mineral density; Ct.BV/TV = cortical bone volume/tissue volume; Ct.Th = cortical thickness; T.Ar = tissue area; TMD = tissue mineral density; P1NP = procollagen type 1 N propeptide; CTX-I = carboxy-terminal telopeptide of type I collagen; MAR = mineral apposition rate; MS/BS = mineralizing surface/bone surface; BFR = bone formation rate; Ob.N/BS = osteoblast number/bone surface.
a
p ≤ 0.05 compared with wild type.