TABLE 4.
Nodes information of the hub miRNA-pathway network.
| Node (miRNA/canonical pathway) | Connectivity degree | Activity |
|---|---|---|
| mmu-let-7b-5p | 16 | ↓↑ |
| mmu-let-7a-5p | 14 | ↓↑ |
| mmu-let-7c-5p | 10 | ↓↑ |
| mmu-miR-106b-3p | 8 | ↑↓ |
| mmu-let-7g-3p | 3 | ↓↑ |
| mmu-let-7g-5p | 1 | ↓↑ |
| mmu-miR-1247-5p | 1 | ↑↓ |
| mmu-let-7b-3p | 1 | ↓↑ |
| mmu-miR-674-5p | 1 | ↑↓ |
| NRF2-mediated Oxidative Stress Response | 4 | ↑↓ |
| IL-8 Signaling | 4 | ↑↓ |
| Leukocyte Extravasation Signaling | 4 | ↑↓ |
| Neuroinflammation Signaling Pathway | 3 | ↑↓ |
| Tec Kinase Signaling | 3 | ↑↓ |
| iCOS-iCOSL Signaling in T Helper Cells | 3 | ↑↓ |
| Th1 and Th2 Activation Pathway | 3 | — |
| Xenobiotic Metabolism Signaling | 3 | — |
| Th1 Pathway | 2 | ↑↓ |
| CD28 Signaling in T Helper Cells | 2 | ↑↓ |
| PXR/RXR Activation | 2 | — |
| PD-1, PD-L1 cancer immunotherapy pathway | 2 | ↓↑ |
| RhoGDI Signaling | 2 | ↓↑ |
| Fc Receptor-mediated Phagocytosis in Macrophages and Monocytes | 2 | ↑↓ |
| T Helper Cell Differentiation | 2 | — |
| Hepatic Fibrosis/Hepatic Stellate Cell Activation | 2 | — |
| Natural Killer Cell Signaling | 2 | — |
| Agranulocyte Adhesion and Diapedesis | 1 | — |
| Atherosclerosis Signaling | 1 | — |
| FXR/RXR Activation | 1 | — |
| Signaling by Rho Family GTPases | 1 | ↑↓ |
| Role of NFAT in Regulation of the Immune Response | 1 | ↑↓ |
| Phagosome Formation | 1 | — |
| Granulocyte Adhesion and Diapedesis | 1 | — |
Connectivity degree, the number of edges between two nodes; up- or down-ward arrow, a MicroRNAs or a canonical pathway is up- or down-regulated; short horizontal line, the activity of a pathway is unkown. p < 0.05.