TABLE 5.
Classification of the canonical pathways regulated by the target miRNAs
| Target miRNA | Canonical pathway | Classification |
|---|---|---|
| mmu-let-7a-5p | Fc Receptor-mediated Phagocytosis in Macrophage and Monocytes | Inflammation/immunity |
| mmu-let-7a-5p | Natural Killer Cell Signaling | Inflammation/immunity |
| mmu-let-7a-5p | FXR/RXR Activation | Cellular functions and signal transduction |
| mmu-let-7a-5p,mmu-let-7b-5p | PD-1, PD-L1 cancer immunotherapy pathway | Inflammation/immunity |
| mmu-let-7a-5p,mmu-let-7b-5p | PXR/RXR Activation | Cellular functions and signal transduction |
| mmu-let-7a-5p,mmu-let-7b-5p | Tec Kinase Signaling | Inflammation/immunity |
| mmu-let-7a-5p,mmu-let-7b-5p | iCOS-iCOSL Signaling in T Helper Cells | Inflammation/immunity |
| mmu-let-7a-5p,mmu-let-7b-5p | Th1 Pathway | Inflammation/immunity |
| mmu-let-7a-5p,mmu-miR-106b-3p | IL-8 Signaling | Inflammation/immunity |
| mmu-let-7a-5p,mmu-let-7b-5p,mmu-miR-106b-3p | Neuroinflammation Signaling Pathway | Inflammation/immunity |
| mmu-let-7a-5p,mmu-let-7b-5p,mmu-let-7g-3p | — | — |
| mmu-miR-106b-3p | Leukocyte Extravasation Signaling | Inflammation/immunity |
| mmu-let-7a-5p,mmu-let-7b-5p | Th1 and Th2 Activation Pathway | Inflammation/immunity |
| mmu-let-7a-5p,mmu-miR-106b-3p | Xenobiotic Metabolism Signaling | Xenobiotic metabolism |
| mmu-let-7a-5p,mmu-let-7b-5p, | — | — |
| mmu-let-7g-3p,mmu-miR-106b-3p | NRF2-mediated Oxidative Stress Response | Oxidative Stress |
| mmu-let-7b-5p | T Helper Cell Differentiation | Inflammation/immunity |
| mmu-let-7b-5p | RhoGDI Signaling | Cellular functions and signal transduction |
| mmu-let-7b-5p | Signaling by Rho Family GTPases | Cellular functions and signal transduction |
| mmu-let-7b-5p | Role of NFAT in Regulation of the Immune Response | Inflammation/immunity |
| mmu-let-7b-5p | Hepatic Fibrosis/Hepatic Stellate Cell Activation | Liver fibrosis |
| mmu-let-7b-5p,mmu-let-7g-3p, | CD28 Signaling in T Helper Cells | Inflammation/immunity |
| mmu-miR-106b-3p | Atherosclerosis signaling | Atherosclerosis |
| mmu-miR-106b-3p | Agranulocyte Adhesion and Diapedesis | Inflammation/immunity |
| mmu-miR-106b-3p | Granulocyte Adhesion and Diapedesis | Inflammation/immunity |
miRNA, MicroRNAs.