Table 1.
Effects of test compounds on planktonic growth of A. baumannii clinical strains
| Compounds | Range (μg/mL) | MIC50 (μg/mL) | MIC90 (μg/mL) | GM-MIC, μg/mL (μM) | GM-MBC, μg/mL (μM) |
|---|---|---|---|---|---|
| MPM | 16–64 | 32 | 64 | 44.42 (ND) | ND |
| IPM | 32–128 | 64 | 128 | 61.54 (ND) | ND |
| Phen | 12.5–25 | 12.5 | 12.5 | 12.98 (70.46 μM) | 36.53 (184.28 μM) |
| Phendione | 1.562–6.25 | 1.562 | 1.562 | 1.98 (9.44 μM) | 2.04 (9.70 μM) |
| Ag-phendione | 1.562 | 1.562 | 1.562 | 1.562 (2.48 μM) | 2.28 (3.63 μM) |
| Cu-phendione | 1.562 | 1.562 | 1.562 | 1.562 (1.63 μM) | 2.22 (2.30 μM) |
| AgNO3 | 6.25–12.5 | 6.25 | 6.25 | 6.73 (39.6 μM) | ND |
| CuSO4·5H2O | > 200 | > 200 | > 200 | ND | ND |
MIC50 and MIC90, correspond to the minimum concentration of test compound required to inhibit 50% and 90% of the clinical bacterial strains, respectively
MPM meropenem, IPM imipenem, phen 1,10-phenanthroline, phendione 1,10-phenanthroline-5,6-dione, Ag-phendione [Ag(phendione)2]ClO4, Cu-phendione [Cu(phendione)3](ClO4)2·4H2O, GM-MIC geometric mean of MIC, GM-MBC geometric mean of MBC, ND not determined