Table 6.
Net monetary benefit at alternative values of the cost-effectiveness threshold–imputed cases using net benefit regression
| Models estimated | Net benefit regression, unadjusted model N = 12,532 imputed observations |
Net benefit regression, adjusted for month in year, and trust site as a mixed effect N = 12,532 imputed observations |
Net benefit regression, adjusted for month in year, trust site as a covariate, and baseline variables N = 12,532 imputed observations |
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|---|---|---|---|---|---|---|---|---|---|
| Comparator mean | Implementation mean | Interaction (95% CI) | Comparator mean | Implementation mean | Interaction (95% CI) | Comparator mean | Implementation mean | Interaction (95% CI)a | |
| Monetary benefit and net monetary benefit at λ = £20,000 | |||||||||
| Monetary benefit in ‘pre’ period | £10,580 | £12,270 | £282 (− 524 to 1088) | £9942 | £12,380 | −£1099 (− 1902 to − 296) | £9997 | £12,356 | −£1,089 (− 1891 to − 297) |
| Monetary benefit in ‘post’ period | £12,148 | £14,119 | £12,867 | £14,206 | £12,898 | £14,168 | |||
| Cost-effectiveness statisticsa | |||||||||
| NMB at λ = £5000 (95% CI) | £263 (− 452 to 977) | −£1019 (− 1773 to − 305) | −£1013 (− 1727 to − 299) | ||||||
| Probability cost effective at λ = £5000 | 0.76 | 0.00 | 0.00 | ||||||
| NMB at λ = £10,000 (95% CI) | £269 (− 464 to 1002) | −£1046 (− 1778 to − 315) | −£1039 (− 1770 to − 308) | ||||||
| Probability cost effective at λ = £10,000 | 0.75 | 0.00 | 0.00 | ||||||
| NMB at λ = £30,000 (95% CI) | £294 (− 622 to 1210) | −£1150 (− 2063 to − 237) | −£1137 (− 2048 to − 227) | ||||||
| Probability cost effective at λ = £30,000 | 0.74 | 0.01 | 0.01 | ||||||
| NMB at λ = £50,000 (95% CI) | £319 (− 884 to 1523) | −£1249 (− 2452 to − 45) | −£1231 (− 2428 to − 35) | ||||||
| Probability cost effective at λ = £50,000 | 0.70 | 0.02 | 0.02 | ||||||
a Threshold values represent cost per death avoided at 90 days
CI confidence interval, NMB net monetary benefit, λ = cost-effectiveness threshold value