Care bundles for chronic obstructive pulmonary disease (COPD) are a set of standardised, evidence-based interventions that may improve outcomes in hospitalised COPD patients.

We estimated the cost effectiveness of care bundles for acute exacerbations of COPD using routinely collected observational data. We compared hospital costs with 90-day mortality in 14 hospitals that implemented care bundle interventions to varying degrees.

COPD care bundles were associated with slightly lower secondary care costs, but there was no evidence that they improved mortality. There was no evidence that care bundles were likely to be cost effective for COPD.