TABLE 4.
The MICs of Pep05 and the derivatives against standard strains.
| Peptides | MIC (μg/mL) |
||||||
| E. coli ATCC 25922 | P. aeruginosa ATCC 27853 | CRPA SIPI-012 | A. baumannii ATCC 19606 | CRAB SIPI-025 | S. aureus ATCC 25923 | C. albicans ATCC 10231 | |
| Pep05 | 1 | 2 | 4 | 2 | 2 | 1 | 4 |
| LP01 | 2 | 1 | 4 | 2 | 2 | 1 | 4 |
| LP02 | 2 | 2 | 8 | 2 | 4 | 1 | 8 |
| DP03 | 1 | 1 | 8 | 2 | 2 | 1 | 4 |
| DP04 | 1 | 1 | 4 | 2 | 1 | 0.5 | 4 |
| DP05 | 2 | 1 | 8 | 1 | 2 | 1 | 2 |
| DP06 | 1 | 1 | 8 | 1 | 2 | 0.5 | 2 |
| UP07 | 1 | 1 | 4 | 2 | 2 | 1 | 4 |
| UP08 | 2 | 2 | 4 | 2 | 2 | 1 | 4 |
| UP09 | 2 | 2 | 4 | 2 | 2 | 1 | 4 |
| UP10 | 2 | 1 | 4 | 2 | 2 | 0.5 | 4 |
| UP11 | 2 | 2 | 8 | 2 | 2 | 1 | 4 |
| UP12 | 2 | 2 | 4 | 2 | 4 | 1 | 4 |
| UP13 | 2 | 2 | 4 | 2 | 2 | 0.5 | 4 |
| UP14 | 2 | 2 | 8 | 4 | 4 | 0.5 | 4 |
| UP15 | 2 | 1 | 4 | 2 | 2 | 1 | 4 |
| Colistin | 0.25 | 0.5 | 1 | 0.25 | 0.25 | / | / |
| Van | / | / | / | / | / | 0.5 | / |
| AmB | / | / | / | / | / | / | 0.25 |
CRPA SIPI-012 represents clinical isolate of carbapenem-resistant P. aeruginosa. CRAB SIPI-025 represents clinical isolate of carbapenem-resistant A. baumannii. Van, vancomycin hydrochloride; AmB, Amphotericin B. “/” represents “not suitable for this test”.